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In rare cases, adults who have recovered from COVID-19 may develop multisystem inflammatory syndrome, and clinicians should consider this possibility in adults with specific symptoms, as physicians describe in a case published in CMAJ (Canadian Medical Association Journal). Link naar het originele artikel

Those who wish to gain practical tools for living optimally with rare diseases are encouraged to attend the annual Living Rare Living Stronger Patient and Family Forum, hosted by the National Organization for Rare Disorders (NORD) and set this year for June 26-27. The conference brings together patients, families, healthcare professionals, and other supporters for learning, sharing, and connecting. Due to the ongoing COVID-19 pandemic, the general sessions, breakout workshops, and networking will again be virtual. The sessions, which will offer perspectives from patients, caregivers, and the

Interluekin-1α (IL-1α) is an important part of the immune response, but until now it has been unclear how this molecule is processed from its precursor, pro-IL-1α, and exits the cell during inflammasome activation. Now, researchers from Japan have found that gasdermin D, a protein that was already known to mediate pyroptosis, a form of regulated cell death, plays a crucial role in the maturation and release of IL-1α. Link naar het originele artikel

(HealthDay)—Higher body mass index (BMI) seems to be associated with an increased risk for developing psoriasis, according to a study published online June 9 in the Journal of the American Academy of Dermatology. Link naar het originele artikel

“The secret of change is to focus all of your energy not on fighting the old, but on building the new.” — Dan Millman Now that some of the pandemic-era restrictions are being lifted throughout the U.S., I can’t help but feeling like I missed a good deal of my life. Until recently, I hadn’t been hospitalized since February 2020, when I had a sarcoidosis flare-up. But in the last two weeks, I’ve been hospitalized twice. On Mother’s Day last month, I was admitted for edema. About a week after I was released, I was readmitted for diverticulitis. The first visit lasted a week, while the second w

Acute and prolonged food-induced inflammation can increase the predicted risk of developing cardiometabolic diseases like cardiovascular disease, new research has shown. Link naar het originele artikel

Johns Hopkins Medicine researchers have identified a protein—DMBT1S8—as a target for potential therapies to treat inflammation in the nasal and sinus cavities. Link naar het originele artikel

Although it was first reported in 1880, there has been little research conducted on prurigo nodularis (PN), an inflammatory chronic skin disorder characterized by firm, intensely itchy nodules that appear across the arms, legs and torso. PN disrupts the sleep and quality of life of those afflicted, and while its cause is largely unknown, it's often linked to additional health complications such as cardiovascular disease, chronic kidney disease and type 2 diabetes. It also disproportionately affects African Americans. Link naar het originele artikel

A cell-penetrating peptide developed by researchers at Vanderbilt University Medical Center can prevent, in an animal model, the often-fatal septic shock that can result from bacterial and viral infections. Link naar het originele artikel

Eurordis opened a campaign, called Rare 2030 Action, that is seeking to establish a European action plan for rare diseases to ensure that none of the 30 million people in Europe living with rare diseases are left behind by the start of a new decade. As part of the campaign, rare disease patients and their caregivers, family members, and others are being invited use an online form to tell Ursula von der Leyen, president of the European Commission, why Europe needs to act now to ensure a better future for them by 2030. The campaign is also seeking engagement on social media, using the hashtag

A researcher investigating pathogens — disease-causing microorganisms — capable of causing neurosarcoidosis has been awarded $150,000 from the Foundation for Sarcoidosis Research (FSR). The FSR Sarcoidosis Research Fellowship Grant will provide Paula Barreras, MD, of the Johns Hopkins University Hospital, with two years of funding for her project. Titled “Discovering pathogens in neurosarcoidosis: using next generation immunological and metagenomic methods for unbiased pathogen detection and antimicrobial antibody profiling,” the study will seek to determine what causes the rare inflammatory

Treating patients with acute respiratory failure is a constant challenge in intensive care medicine. In most cases, the underlying cause is lung inflammation triggered by a bacterial infection or—more rarely, despite being frequently observed at present due to the corona pandemic—a viral infection. During the inflammation, cells of the immune system—the white blood cells—migrate to the lungs and fight the pathogens. At the same time, however, they also cause 'collateral damage' in the lung tissue. If the inflammatory reaction is not resolved in time, this can result in chronic inflammation wit

Ahead of this year’s Rare Disease Week on Capitol Hill, held virtually July 14–22, the EveryLife Foundation will award grants to top advocates of rare disease organizations who participate in the week’s pre-events. The top 50 point-earners will be eligible to win $1,000 to $5,000in grants, totaling up to $100,000, the foundation announced in a release. The pre-event Meet and Greet Session, to be held June 8 and 9, brings together regional and state-wide rare disease advocates to interact in virtual games and prize sessions. Registration is available through this link. Participants can sele

African American women diagnosed with sarcoidosis or who have strong connections to the sarcoidosis community, are invited to apply to become members of the Women of Color Committee of the Foundation for Sarcoidosis Research (FSR). The FRS Committee aims to provide insight into a large-scale education and awareness campaign about sarcoidosis and African American Women. Committee members also will “serve as the face and voice of this campaign, using their personal stories and experiences to educate and increase awareness of sarcoidosis in African American women in communities nationwide,” FSR

(HealthDay)—Individuals with co-occurrence of vitiligo and psoriasis have an increased risk for autoimmunity and family history of psoriasis, according to a research letter published online May 20 in the Journal of the European Academy of Dermatology and Venereology. Link naar het originele artikel

A team of international researchers has found that the Tsimane Indigenous people of the Bolivian Amazon experience less brain atrophy than their American and European peers. The decrease in their brain volumes with age is 70% slower than in Western populations. Accelerated brain volume loss can be a sign of dementia. Link naar het originele artikel

As a means of providing long-term relief from chronic pain, flotation tanks simply don't hold water, new research reveals. Link naar het originele artikel

I was diagnosed with Parkinson's disease 5 years ago,i started azilect,then mirapex as the disease progressed in February last year,and I started on parkinson disease herbal medicine from ultimate life clinic,few months into the treatment I made a significant recovery,almost all my symptoms are gone,great improvement with my movement and balance,it has been a year and life has been so good for me,reach them through there website at www.ultimatelifeclinic.com

I was diagnosed of parkinson disease 5 years ago,i started azilect,then mirapex as the disease progressed in february last year,and i started on parkinson disease herbal medicine from ultimate life clinic,few months into the treatment i made a significant recovery,almost all my symptoms are gone,great improvement with my movement and balance,it been a year and life has been so good for me,reach them through there website at www.ultimatelifeclinic.com

I was diagnosed of parkinson disease 5 years ago,i started azilect,then mirapex as the disease progressed in february last year,and i started on parkinson disease herbal medicine from ultimate life clinic,few months into the treatment i made a significant recovery,almost all my symptoms are gone,great improvement with my movement and balance,it been a year and life has been so good for me,reach them through there website at www.ultimatelifeclinic.com

I was diagnosed of parkinson disease 5 years ago,i started azilect,then mirapex as the disease progressed in february last year,and i started on parkinson disease herbal medicine from ultimate life clinic,few months into the treatment i made a significant recovery,almost all my symptoms are gone,great improvement with my movement and balance,it been a year and life has been so good for me,reach them through there website at www.ultimatelifeclinic.com

I was diagnosed of parkinson disease 5 years ago,i started azilect,then mirapex as the disease progressed in february last year,and i started on parkinson disease herbal medicine from ultimate life clinic,few months into the treatment i made a significant recovery,almost all my symptoms are gone,great improvement with my movement and balance,it been a year and life has been so good for me,reach them through there website at www.ultimatelifeclinic.com

As a teen, I got a T-shirt from my best friend that said “Me, paranoid? Who wants to know?” So, you see, trusting maskless strangers to be fully vaccinated just isn’t in my nature. We are still in a pandemic. With sarcoidosis, two shots in the arm doesn’t mean we can let our guard down, as I was recently reminded. There are still plenty of unknowns, such as how long immunity will last and whether protection against emerging variants will, too. And sometimes we overlook what’s right in front of us in our efforts to stay safe. I have done so on multiple occasions recently. The first was a

Mother’s Day was a couple weeks ago here in the U.S., but I must admit, I’m not a big fan of the holiday. Let me explain. On Mother’s Day weekend in 2003, I suddenly lost my mother. I had just returned to work after having an outpatient procedure to remove sinus polyps. At the time, it didn’t dawn on me that the polyps probably were related to my pulmonary sarcoidosis, since all of it involved my respiratory system. But I don’t recall having been diagnosed yet. Anyway, my mom was with me during the surgery, which happened a few days after her 64th birthday. When it was over, I remember her

Greater skin clearance among psoriasis patients is associated with greater improvements in quality of life, according to a letter to the editor published in the June issue of the Journal of the American Academy of Dermatology. Link naar het originele artikel