Small intestine contributes to chronic inflammation in obesity

[Joachim]

Obesity is caused by numerous and complex factors, some of which are as yet unsuspected. Scientists from the CNRS, INSERM, UPMC and Université Paris Descartes, working with research clinicians from Paris Public Hospitals (AP-HP) have now shown that severe obesity is accompanied by inflammation of the small intestine and enhanced immune response in that region. This phenomenon reduces the insulin sensitivity of enterocytes1 and increases the absorption of nutrients, thus exacerbating the disease. This work, carried out at the Centre de Recherche des Cordeliers (INSERM/UPMC/Université Paris Descartes) and the Institut de Cardiométabolisme et Nutrition (ICAN - INSERM/UPMC/AP-HP), is published on 18 June in Cell Metabolism.

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