Bacteria in the bile duct may provide a new clue for treating liver disease

[Joachim]

Primary sclerosing cholangitis (PSC) is a disease in which inflammation causes scars in the bile duct, leading to liver failure, infections, and tumors. Up to 80% of PSC patients have inflammatory bowel disease. Major aspects of PSC pathophysiology are unknown. There is no pharmaceutical therapy, and liver transplantation is the only curative treatment. Now, investigators have established that mucosal-associated T (MAIT) cells, which are present in a range of diseases, also potentially play an important role in the pathophysiology of PSC that can have implications for treatment. Their work is presented in The American Journal of Pathology.

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