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Quercetin gebruik bij Sarcoidose


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Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis.

 

http://www.ildcare.eu/Downloads/proefschriften/proefschriften_2006/Boots_ch09.pdf

 

http://www.ncbi.nlm.nih.gov/pubmed/21324570

 

Boots AW, Drent M, de Boer VC, Bast A, Haenen GR.

 

Department of Pharmacology and Toxicology, Faculty of Medicine, University of Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands. a.boots@maastrichtuniversity.nl

 

Background

 

Oxidative stress and low antioxidant levels are implicated in the etiology of sarcoidosis, an inflammatory disease. Quercetin is a potent dietary antioxidant that was also found to display anti-inflammatory activities.

 

Results

 

This study demonstrated that quercetin supplementation improved the antioxidant defence system, indicated by the increased total plasma antioxidant capacity.....Moreover, this supplementation also reduced markers of oxidative stress and inflammation in sarcoidosis. The effects of the quercetin supplementation appeared to be more pronounced when the levels of the oxidative stress and inflammation markers were higher at baseline.

Conclusions

 

This study indicates that sarcoidosis patients might benefit from the use of antioxidants such as quercetin to reduce the occurring oxidative stress as well as inflammation. Long-term use of antioxidant supplementation in sarcoidosis, using e.g. quercetin, remains to be investigated.

 

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Antioxidant status associated with inflammation in sarcoidosis: a potential role for antioxidants

 

http://www.ildcare.eu/Downloads/proefschriften/proefschriften_2006/Boots_ch08.pdf

 

AW Boots, M Drent, ELR Swennen, HJJ Moonen, A Bast, GRMM Haenen

 

Quercetin is an extremely powerful antioxidant (12) and therefore it is tempting to speculate that quercetin can exert positive effects in sarcoidosis.

Sarcoidosis patients

 

Twenty non-smoking patients with symptomatic sarcoidosis (age 44±1) were enrolled in this study. Patients had been diagnosed with sarcoidosis based on clinical features, together with bronchoalveolar lavage (BAL) fluid analysis results (data not shown) (17). Moreover, 17 out of the 20 sarcoidosis patients had a biopsy confirmation of the disease. The clinical symptoms of all patients included respiratory symptoms, i.e. dyspnea, coughing and chest pain.

 

Results

 

Two endogenous antioxidants that are known to contribute substantially to the total plasma antioxidant status are uric acid and vitamin C. Uric acid levels as well as vitamin C levels were significantly declined in the plasma of sarcoidosis patients (to respectively 60% and 79% of the control levels) compared to their matched controls.

 

Discussion

 

To the best of our knowledge, this study is the first that demonstrates a significant decrease in the total plasma antioxidant capacity as well as in the blood levels of the important endogenous antioxidants GSH, vitamin C and uric acid in sarcoidosis patients compared to healthy controls matched for age, gender and dietary behaviour.

Interestingly, the anti-inflammatory effects of quercetin are much more pronounced in the sarcoidosis patients than in their matched controls. The anti-inflammatory actions of quercetin observed in the present study could very well be related to its anti-oxidative activity.

 

This suggests that particularly in sarcoidosis patients empowering the antioxidant defense system with alimentary antioxidants, such as quercetin, might be fruitful. This is especially important since conventional treatment with glucocorticoids fails to be efficacious.

 

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Daarom eet ik o.a. veel appels, rode ui, broccoli en drink ik voornamelijk groene thee.

Een vrij hoge dossis zit ook in kappertjes! Dat is weer lekker in de (verse) sla.

 

Het gaat met mij hartstikke goed. Geen ontstekings activiteit in het lichaam.

Ik heb 9 maanden lang via capsules een dossis van 900 mg tot mij genomen.

 

Ik zeg het nog niet hartop maar ik ben er waarschijnlijk overheen........ de tijd zal het leren, en ik blijf mij aan het dieet houden.

Ik sport weer volop, heb een startbewijs voor de Elf stedentocht dit jaar en die had ik gereden ook. Dat was een goed jaar geleden ondenkbaar!

 

Gr. John

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