Inflammation accelerates aging of the hematopoietic system

[Joachim]

In mice, inflammation in early to mid-life leads to a permanent decline in functional blood stem cells, according to a recent publication by scientists from the German Cancer Research Center (DKFZ) and the Stem Cell Institute HI-STEM. The ability of the blood stem cells to regenerate was suppressed for at least one year after challenge with inflammation, suggesting that infection and inflammation may act as a prominent driver of age-associated functional decline in tissues. In line with this, mice exposed to such challenges in early life developed clinically relevant features of aging that are often observed in elderly humans.

Link naar het originele artikel